Lipophilicity and Chromatographic Behaviour of Benzoic Acid Derivatives

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概要

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• The Rm values of 32 compounds, derivatives of benzoic acid, were determined by reversed-phase thin layer chromatography (RP-TLC). The logarithm of the capacity factor, log k', of the same compounds was studied with reversed-phase high performance liquid chromatography (RP-HPLC). The lipophilicity was calculated according to the fragmental methods of Rekker and of Leo-Hansch and was compared with the experimental values of Rm and the log k'. The comparison shows that the Rekker method gives a better description of lipophilicity than that of the Leo-Hansch method.

• 公益社団法人日本薬学会の論文
• 1993-02-15

著者

• Koutselinis A

  Univ. Athens Goudi Grc

• Koutselinis Antonios

  Department Of Forensic Medicine And Toxicology School Of Medicine University Of Athens

• PAGOU Margarita

  Department of Forensic Medicine and Toxicology, School of Medicine, University of Athens

• Pagou Margarita

  Department Of Forensic Medicine And Toxicology School Of Medicine University Of Athens

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