SYNTHESIS OF 4'-N-CBZ-PRACIMIC ACID FROM PRADIMICIN A

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概要

• 論文の詳細を見る

• The sterically hindered alanine-amide bond of pradimicin A (PRM A, 1__-) was successfully cleaved via less hindered primary amide (<11>___-)by treatment with NOBF_4 in eight steps to afford practical yield of 4'-N-Cbz-pradimic acid (<13>___-), which is a useful intermediate for the synthesis of alanine-exchanged derivatives.

• 公益社団法人日本薬学会の論文
• 1993-01-15

著者

• 沖 俊一

  Bristol-myers Squibb Research Institute Bristol-myers Squibb K.k.

• 奥山 さつき

  Bristol-Myers Squibb Research Institute, Bristol-Myers Squibb K.K.

• 蒲地 一

  Bristol-Myers Squibb Research Institute, Bristol-Myers Squibb K.K.

• 奥山 さつき

  Bristol-myers Squibb Research Institute Bristol-myers Squibb K.k.

• 蒲地 一

  Bristol-myers Squibb Research Institute Bristol-myers Squibb K.k.

関連論文

• Preparation and Antitumor Activity of 2"-O-, 3"-O- and 2", 3"-Di-O-substituted Derivatives of Etoposide
• SYNTHESIS OF 4'-N-CBZ-PRACIMIC ACID FROM PRADIMICIN A

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