Synthesis and Antiplatelet Activities of N-Arylmethyl-3,4-dimethylpyrano[2,3-c]pyrazol-6-one Derivatives

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概要

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• A series of new 1- and 2-arylmethyl-3,4-dimethylpyrano[2,3-c]pyrazol-6-one derivatives were synthesized and examined for their antiplatelet activities. Some of these compounds showed significant inhibitory activities. Among them, 1-phenylmethyl-3,4-dimethylpyrano[2,3-c]pyrazol-6(1H)-one (4a), 2-(2'-methoxyphenyl)methyl-3,4-dimethyl-pyrano[2,3-c]pyrazol-6(2H)-one (3e) and 2-(3'-methoxyphenyl)methyl-3,4-dimethylpyrano[2,3-c]pyrazol-6-(2H)-one (3f) were the most effective. These inhibitors acted in a consentration-dependent manner. The antiplatelet effect of compound 3f is due to the inhibition of thromboxane A_2 formation and the blockade of thromboxane A_2/prostaglandin endoperoxide receptor in washed rabbit platelets.

• 公益社団法人日本薬学会の論文
• 1992-09-25

著者

• 〓 哲明

  Republic Of China And Pharmacological Institute College Of Medicine National Taiwan University

• 黄 麗嬌

  Graduate Institute Of Pharmaceutical Chemistry China Medical College

• 郭 盛助

  Graduate Institute Of Pharmaceutical Chemistry China Medical College

• 候 曼貞

  Graduate Institute of Pharmaceutical Chemistry, China Medical College

• 候 曼貞

  Graduate Institute Of Pharmaceutical Chemistry China Medical College

関連論文

• Studies on Heterocyclic Compounds. X. : Dealkoxycarbonylation of Ethyl 2-Arylamino-4-oxo-4,5-dihydrofuran-3-carboxylates
• Synthesis and Antimicrobial Activity of Methyl 5-Nitro-3,4-diphenylfuran-2-carboxylate and Related Compounds
• Synthesis and Antiallergic Activities of 2-Alkyl-3,4-dimethylfuro[2,3-c]pyrazole-5-carboxamides and Related Compounds
• Synthesis and Antiplatelet Activities of N-Arylmethyl-3,4-dimethylpyrano[2,3-c]pyrazol-6-one Derivatives

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