Isolation of a Metastasizing Cancer Cell Line from an Aflatoxin B_1-Induced Rat Liver Tumor
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概要
- 論文の詳細を見る
An attempt was made to isolate cancer cell lines from liver tumors that had been induced by aflatoxin B_1 (AFB_1) in rats. A clonal cell line named AFB-1 was isolated from a liver tumor that was histologically diagnosed as hepatocellular carcinoma. When AFB-1 cells were inoculated into the subcutaneous tissue at the dorsal region of syngenic animals, they metastasized from the site of inoculation into the abdominal cavity to form many tumor nodules throughout the serous membrane and metstatic foci in the kidney and pancreas. They also metastasized into the thoracic cavity to form metastatic foci in the lung. This is the first instance where a metastasizing AFB_1-induced cancer cell line has been isolated.
- 社団法人日本薬学会の論文
- 1992-05-25
著者
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黒田 啓子
千葉大学真核微生物センター
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岸川 正剛
Department Of Environmental Pathology School Of Environmental Health Azabu University
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赤尾 三太郎
Department of Chemico-Biological Interactions, Research Center for Pathogenic Fungi and Microbial To
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黒田 啓子
Department of Chemico-Biological Interactions, Research Center for Pathogenic Fungi and Microbial To
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五ノ井 透
Department of Chemico-Biological Interactions, Research Center for Pathogenic Fungi and Microbial To
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五ノ井 透
Department Of Chemico-biological Interactions Research Center For Pathogenic Fungi And Microbial Tox
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赤尾 三太郎
千葉大学真菌医学研究センター
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