Abrogation of the Suppressive Effect of 12-O-Tetradecanoylphorbol 13-Acetate and 7,12-Dimethylbenz[α]anthracene on Footpad Reaction of Mice by Indomethacin and Some Inhibitors of Tumor Promotion

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Influences of indomethacin, which has been known as an inhibitor of the production of prostaglandins, on the suppression of footpad reaction (FPR) of BALB/c mice against sheep red blood cells by the painting of 12-O-tetradecanoylphorbol 13-acetate (TPA, a typical tumor promoter) were studied. The temporary suppressive effect by the painting of TPA (8nmol) was abrogated by the painting of indomethacin (7-70nmol) 60min before TPA treatments. The lasting suppressive effect by TPA treatment (8nmol/d) for 7d following the painting of 7,12-dimethylbenz[α]anthracene (DMIBA, 400nmol), which is a typical tumor initiator, also disappeared when indomethacin (7nmol) was painted 30-90min before each TPA treatment.Influences of some inhibitors of tumor promotion on the lasting suppressive effect of FPR by DMBA and TPA were also tested. Painting of 0.6μmol of 1-phenyl-2-pyrazolidone, 8.2nmol of salcophytol A, 17nmol of retinoic acid, 5.6μmol of 3(2)-tert-butyl-4-hydroxyanisol, and 3μmol of quercetin 45min before each TPA treatment decreased the suppressive effect on the footpad reaction.
社団法人日本薬学会の論文
1992-02-25