Synthesis of Alkylamino Derivatives of 1,4,6,11-Tetrahydropyridazino[1,2-b]phthalazine-6,11-dione

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概要

• 論文の詳細を見る

• The synthesis of 7-[(3-N, N-dimethylamino)propylamino]-1,4,6,11-tetrahydropyridazino[1,2-b]phthalazine-6,11-dione derivatives is reported. The expected monoalkylamino substituted derivative (4a) was obtained from the 7-chloro-substituted compound (3a), whereas the 7,10-dichloro-substituted compound (3b) gave a mixture of the monoalkylamino derivative (4b) and the dialkylaminophthalimide (4c). The cytotoxic activity of 4a-c against HeLa cells was assayed. Compounds 4a and 4b showed a higher cytotoxicity than the starting adducts (3a and 3b).

• 公益社団法人日本薬学会の論文
• 1992-11-25

著者

• Navarro Pilar

  Instituto De Quimica Medica C.s.i.c.

• Gomez‐contreras F

  Univ. Complutense Madrid Esp

• CAMPAYO Lucrecia

  Instituto de Quimica Medica, C.S.I.C.

• GOMEZ-CONTRERAS Fernando

  Departamento de Quimica Organica I, Facultad de Ciencias Quimicas, Universidad Complutense

• Campayo L

  Univ. Complutense Madrid Esp

関連論文

• Binuclear Pyrazoles. I. Synthesis and Cytotoxic Activity of 1,1'-Dibenzyl and 1,1'-Dihydroxymethyl 4,4'-Bispyrazoles
• Synthesis of Alkylamino Derivatives of 1,4,6,11-Tetrahydropyridazino[1,2-b]phthalazine-6,11-dione

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