Protein Kinase Inhibitor H-7 Increases Lipoprotein Lipase Activity in Isolated Rat Fat Pads
スポンサーリンク
概要
- 論文の詳細を見る
A protein kinase inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7) increased lipoprotein lipase (LPL) activity in isolated rat fat pads in a time- and dose-dependent manner. The incubation of H-7 with partially purified LPL did not affect its activity. Under the marked inhibition of protein synthesis by cycloheximide, H-7 still showed a full effect on the increase in LPL activity. A slight but significant increase in LPL activity in the fat pads was observed with inhibitors of cyclic nucleotide-dependent protein kinase. H-7,therefore, may increase LPL activity through processes other than the direct activation of the LPL molecule, or the stimulation of LPL molecule synthesis; probably through a decrease in the activity of protein kinases, especially protein kinase C.
- 公益社団法人日本薬学会の論文
- 1991-09-25
著者
-
森田 哲生
Department of Biochemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
-
植木 寛
Department of Biochemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
-
鶴薗 保幸
福山大学
-
鶴薗 保幸
Department of Biochemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
関連論文
- Stimulatory Release of Hepatic Lipase Activity from Cultured Rat Hepatocytes by Sodium Orthovanadate : Rapid Increase in Cyclic Adenosine Monophosphate Content
- Stimulatory Release of Lipoprotein Lipase Activity with Activation of Protein Tyrosine Kinase Produced by Low Molecular Weight Dextran Sulfate in Ehrlich Ascites Tumor Cells
- The Structure and Function of Carboxypeptidase C_N
- Anticoagulant Action of Vanadate
- Inhibition by Equine α_2-Macroglobulin of an N-Succinyl-L-Trialanine p-Nitroanilide-Hydrolyzing Protease Purified from Pronase
- Regulation of Cyclic AMP Phosphodiesterase Activity by Particulate Protein Tyrosine Kinase and Phosphotyrosine Phosphatase Activities Sensitive to Sodium Orthovanadate
- Stimulatory Release of Hepatic Lipase Activity from Liver by Epidermal Growth Factor
- バナデートによるラット脂肪組織中のイノシトール1,4,5-三リン酸の急速な増加(発表論文抄録(1991年))
- RAPID INCREASE OF INOSITOL 1,4,5-TRISPHOSPHATE CONTENT IN ISOLATED RAT ADIPOSE TISSUE BY VANADATE
- Vanadate-Stimulated Release of Hepatic Lipase Activity from Liver
- Increase in Lipoprotein Lipase Activity in Isolated Rat Adipose Tissue by Selenate
- Inhibitino of Increasing Effect of Vanadate on Glycogen Content and Lipoprotein Lipase Activity in Fat Pads by 5-N, N-Hexamethylene Amiloride
- バナデートによる脂肪組織中のイノシトール1, 4, 5-三リン酸の形成(発表論文抄録(1991年))
- Protein Kinase Inhibitor H-7 Increases Lipoprotein Lipase Activity in Isolated Rat Fat Pads