MALE-SPECIFIC METABOLISM OF SIMVASTATIN BY RAT LIVER MICROSOMES

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概要

• 論文の詳細を見る

• Simvastatin was more effectively metabolized by the liver microsomes of male rats than females. The sex difference appeared in the composition of the metabolites. Two male-specific metabolites were identified by NMR and mass spectrometry as 3"-hydroxy and 3', 3"-dihydroxy-Δ4', 5' derivatives of simvastatin.

• 公益社団法人日本薬学会の論文
• 1991-01-25

著者

• 内山 尚孝

  Central Research Laboratories, Banyu Pharmaceutical Co., Ltd.,

• 大多和 昌克

  Central Research Laboratories, Banyu Pharmaceutical Co., Ltd.,

• 加々見 弥生

  Central Research Laboratories Banyu Pharmaceutical Co. Ltd.

• 斎藤 由子

  Central Research Laboratories Banyu Pharmaceutical Co. Ltd.

• 内山 尚孝

  Central Research Laboratories Banyu Pharmaceutical Co. Ltd.

• 大多和 昌克

  Central Research Laboratories Banyu Pharmaceutical Co. Ltd.

関連論文

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• Quantitative Determination of Forphenicinol and Its Metabolites in Human Serum and Urine by Gas Chromatography : Mass Spectrometry with Selected Ion Monitoring
• MALE-SPECIFIC METABOLISM OF SIMVASTATIN BY RAT LIVER MICROSOMES

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