Hepatorotective Compounds from Canarium album and Euphorbia nematocypha
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概要
- 論文の詳細を見る
Successive purification of the extract from Canarium album and Euphorbia nematocypha, guided by antihepatotoxic activity in primary cultured rat hepatocytes, led to the isolation of brevifolin (1), hyperin (2), ellagic acid (3) and 3,3'-di-O-methylellagic acid (4) as hepatoprotective compounds. Compounds 1,3 and 4 also reduced carbon tetrachloride (CCl_4)-induced liver damage in mice. The hapatoprotective activities of 1,2,3 and 4 in vitro and in vivo are apparently due to their antioxidative effects, which were exhibited by further studies using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and CCl_4-induced lipid peroxidation systems.
- 公益社団法人日本薬学会の論文
- 1990-08-25
著者
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渡辺 修治
Research Center Taisho Pharmaceutical Co. Ltd.
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伊藤(旧姓染谷) まゆみ
Research Center Taisho Pharmaceutical Co. Ltd.
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新井 巌
Research Center Taisho Pharmaceutical Co. Ltd.
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玉井 正晴
Research Center, Taisho Pharmaceutical Co., Ltd.,
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花田 和紀
Research Center, Taisho Pharmaceutical Co., Ltd.,
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志村 洋史
Research Center, Taisho Pharmaceutical Co., Ltd.,
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高橋 晶子
Research Center, Taisho Pharmaceutical Co., Ltd.,
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田中 善孝
Research Center, Taisho Pharmaceutical Co., Ltd.,
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張 佩玲
Institute of Materia Medica, Chinese Academy of Medical Sciences
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〓 暢
Institute of Materia Medica, Chinese Academy of Medical Sciences
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陳 未名
Institute of Materia Medica, Chinese Academy of Medical Sciences
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楊 峻山
Institute of Materia Medica, Chinese Academy of Medical Sciences
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〓 〓佗
Institute of Materia Medica, Chinese Academy of Medical Sciences
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WANG Yu-Lan
Institute of Materia Medica, Chinese Academy of Medical Sciences
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楊 峻山
Institute Of Materia Medica Chinese Academy Of Medical Sciences
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花田 和紀
Research Center Taisho Pharmaceutical Co. Ltd.
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玉井 正晴
Research Center Taisho Pharmaceutical Co. Ltd.
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Wang Yu-lan
Institute Of Materia Medica Chinese Academy Of Medical Sciences
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田中 善孝
Research Center Taisho Pharmaceutical Co. Ltd.
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高橋 晶子
Research Center Taisho Pharmaceutical Co. Ltd.
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張 佩玲
Institute Of Materia Medica Chinese Academy Of Medical Sciences
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志村 洋史
Research Center Taisho Pharmaceutical Co. Ltd.
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陳 未名
Institute Of Materia Medica Chinese Academy Of Medical Sciences
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〓 〓佗
Institute Of Materia Medica Chinese Academy Of Medical Sciences
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〓 暢
Institute Of Materia Medica Chinese Academy Of Medical Sciences
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