Studies on Fe Complexes Produced by Yeast. V. : Role of the Ligand in Fe Absorption from an Fe(II)-Oligosaccharide Complex

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概要

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• The role of the ligand (oligosaccharide) of an Fe(II) complex (B1-c) produced in wine by Saccharomyces cerevisiae in gastrointestinal Fe absorption was examined. B1-c was found to consist of Fe(II) and an oligosaccharide having the composition of Ara : Xyl : Man : Glc : GalUA (1 : 1 : 1 : 5 : 1), and the sequence of these constituent monosaccharides was presumed by means of partial hydrolysis of B1-c with glycosidases and a diluted acid. The physicochemical comparison of the partially hydrolyzed, Fe(II)-containing products (Fe-containing fragments) obtained by glycosidase treatment indicated that the Man and GalUA residues of the ligand should be essential for stabilization of the complex form at the physiological pH in the digestive tract. The intestinal Fe absorption in vivo showed marked differences among the Fe-containing fragments having different ligands (sugar chains). Furthermore, the inhibitory effets of the Fe-containing fragments on B1-c uptake by brush border membrane vesicles of the small intestine varied with the ligand, probably being related to the composition of the sugar chain. These results suggest that the sugar chain of the ligand of B1-c may be involved, through its coordination with Fe(II), in (i) high stability and Fe solubility of B1-c at the physiological pH in the digestive tract and (ii) recognition of B1-c molecules in its transport system on the intestinal brush border membrane and, thereby, may contribute to excellent intestinal Fe absorption from B1-c.

• 公益社団法人日本薬学会の論文
• 1990-10-25

著者

• 田中 健太郎

  Faculty Of Technology Yamanashi University

• 田端 滋

  Pharma Research Laboratories Hoechst Japan Limited

関連論文

• Studies on Fe Complexes Produced by Yeast. V. : Role of the Ligand in Fe Absorption from an Fe(II)-Oligosaccharide Complex
• Studies on Fe Complexes Produced by Yeast. IV. : Mechanism of Fe Transport from an Fe(II)-Oligosaccharide Complex across the Mucosal Membrane of the Rat Intestine
• Studies on Fe Complexes Produced by Yeast. III. : Characteristics of Fe Absorption from an Fe(II)-Oligosaccharide Complex in the Rat Gastrointestinal Tract
• Studies on Fe Complexes Produced by Yeast. I. Separation of Fe Complexes from Wine and Their Incorporation into Hemoglobin in Rats(Biological)

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