Heterocyclic Quinones. XVI. : Pharmacomodulation in the Series of 11H-Indolo[3,2-c]quinolinediones : Synthesis, Cytotoxicity and Antitumor Activity of 3-Substituted 11H-Pyrido[3', 4' : 4,5]pyrrolo[3,2-c]quinoline-1,4-diones
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概要
- 論文の詳細を見る
With the aim of obtaining new antitumor drugs more active than previously described 11H-indolo[3,2-c]quinoline-1,4-diones and 7,8,9,10-tetrahydro-11H-indolo[3,2-c]quinoline-1,4-diones, the synthesis and activities of a series of 3-substituted 11H-pyrido[3', 4' : 4,5]pyrrolo[3,2-c]quinoline-1,4-diones and of 7,8,9,10-tetrahydro-11H-pyrido-[3', 4' : 4,5]pyrrolo[3,2-c]quinoline-1,4-diones were studied. Some quinones were more cytotoxic in vitro towards L1210 leukemia cells but were not active in vivo towards murine P388 leukemia.
- 社団法人日本薬学会の論文
- 1989-09-25
著者
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Giorgi-renault Sylviane
Laboratorie De Recherche Sur Les Heterocycles Azotes Department De Chimie Organique Faculte Des Scie
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Cros Suzanne
Laboratoire De Pharmacologie Et De Toxicologie Fondamentales Du Cnrs
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HELISSEY Phillippe
Laboratoire de Recherche sur les Heterocycles azotes, Departement de Chimie Organique, Faculte des S
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RENAULT Jean
Laboratoire de Recherche sur les Heterocycles azotes, Departement de Chimie Organique, Faculte des S
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Renault Jean
Laboratorie De Recherche Sur Les Heterocycles Azotes Department De Chimie Organique Faculte Des Scie
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Helissey Philippe
Laboratorie De Recherche Sur Les Heterocycles Azotes Department De Chimie Organique Faculte Des Scie
関連論文
- Heterocyclic Quinones. XVI. : Pharmacomodulation in the Series of 11H-Indolo[3,2-c]quinolinediones : Synthesis, Cytotoxicity and Antitumor Activity of 3-Substituted 11H-Pyrido[3', 4' : 4,5]pyrrolo[3,2-c]quinoline-1,4-diones
- Heterocyclic Quinones.XIV. : Pharmacomodulation in a Series of 11H-Indolo[3,2-c]quinolinediones : Synthesis and Cytotoxicity of 8-Substituted 11H-Indolo[3,2-c]quinoline-7,10-diones
- Heterocyclic Quinones. XIII. : Dimerization in the Series of 5,8-Quinazolinediones : Synthesis and Antitumor Effects of Bis(4-amino-5,8-quinazolinediones)
- A Convenient Synthesis of 1H-Pyrrolo[3,2-c]quinoline-6,9-diones and 11H-Indolo[3,2-c]quinoline-1,4-diones Derivatives(Organic,Chemical)
- Assessing the Potential Leukemogenic Effects of 50Hz Magnetic Fields and their Harmonics Using an Animal Leukemia Model