Stability of Recombinat Human Epidermal Growth Factor in Various Solutions

概要

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The stability of recombinant human epidermal growth factor (hEGF) in various solutions was examined. hEGF degraded spontaneously and temperature-dependently to several degradation products in phosphate buffered saline or in 0.1 N acetic acid. The enzymatic degradation was observed in human serum or in pepsin/HCl solution. The structure and biological activities of these compounds were examined. The results suggest that the Asp^<11> and Trp^<50> residues are important for the receptor binding.
公益社団法人日本薬学会の論文
1989-02-25