A Possible Mechanism of Fever Induced by Nocardia rubra Cell Wall Skeleton (N-CWS) in Experimental Animals

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The characteristics of fever elicited by the cell wall skeleton of Nocardia rubra (N-CWS) and by lipopolysaccharide (LPS) were compared in rabbits, and the possible involvement of the antigenicity of N-CWS was investigated in guinea pigs.In rabbits, fever of more than 0.5℃ developed after an intravenous (i.v.) injection of 10 μg/kg or more of N-CWS, and was monophasic with 30-100 μg/kg but biphasic with the highest dose of 300 μg/kg. LPS elicited fever with similar characteristics at doses of 0.01-0.1 μg/kg. With both compounds, the fever was inhibited by indomethacin. Tolerance to N-CWS and LPS appeared after dosing with 30 or 0.1 μg/kg, respectively for 10 d.In guinea pigs sensitized with N-CWS, challenge with 1 or 10 μg/kg of N-CWS 10 d later, which did not induce fever in the nonsensitized animals, caused fever of more than 0.5℃, and delayed-type hypersensitivity (DTH) appeared. N-CWS also elicited fever in nonsensitized guinea pigs bearing N-CWS-sensitized lymphocytes or anti-N-CWS antibody; the fever was higher in the guinea pigs sensitized with the lymphocytes than in those with the anti-N-CWS antibody.In brief, single injections of N-CWS and of LPS elicited fever with similar characteristics, although the potency of N-CWS was weaker. With N-CWS, the fever is proposed to be triggered by the antigenicity of the compound itself, because doses as low as 1 or 10 μg/kg elicited fever along with immunological response in N-CWS-sensitized animals, but not in nonsensitized ones.
社団法人日本薬学会の論文
1989-10-25

A Possible Mechanism of Fever Induced by Nocardia rubra Cell Wall Skeleton (N-CWS) in Experimental Animals

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