Relationship between Gelatinase Secretion and Chemotaxis of Rat Polymorphonuclear Leukocytes

概要

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In response to chemoattractants, rat polymorphonuclear leukocytes (PMNs)secreted latent gelatinase, which was predominant among PMN neutral proteinases such as collagenase, elastase and cathepsin G. The PMNs highly responsive to chemoattractants migrated earlier than other PMNs and secreted large proportions of their latent gelatinase, though their cellular content of gelationase was at a normal level. The gelatinase species secreted from PMNs were metalloproteinases and have the same molecular weights (96 and 230 kilodaltons) as those of proteinases stored in granules of PMNs. After treatment with an activator, the secreted gelatinase degraded bovine type IV collagen. From these results we hypothesize that there is a population of PMNs that actively migrates and secretes latent gelatinase in response to chemoattractants. The PMNs probably reach the vascular site near the inflammatory lesion faster than other PMNs and secrete large amounts of gelatinase to degrade basement membranes, resulting in the formation of a pathway for extravascular emigration of other PMNs.
公益社団法人日本薬学会の論文
1988-06-25