Aminopyrimidines and Derivatives. XXI. : Synthesis of 5-Acyl-(4-β-D-glycopyranosylamino)pyrimidine Derivatives as Potential Anticancer Agents

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概要

• 論文の詳細を見る

• Acetylation of 4-(O-acetyl-β-D-glycopyranosylamino)-6-oxo-pyrimidines (2a, d, e) with Ac_2O/pyridine at 80℃ gave the 6-acetoxy derivatives 3a, d, e. Although these were also obtained by treatment with Ac_2O/H_2SO_4,prolonged reactions of 2a-c, e-f gave the 5-acetyl derivatives 4a-c, e-f. The Vilsmeier reaction of 2b-g produced the 5-formyl derivatives 5b-g, whereas 2a gave the uracil derivative 9 under similar conditions.

• 公益社団法人日本薬学会の論文
• 1988-01-25

著者

• Sanchez Adolfo

  Department Of Organic Chemistry University College Of Jaen University Of Granada

• NEGRILLO JACINTO

  Department of Organic Chemistry, University College of Jaen, University of Granada

• NOGUERAS MANUEL

  Department of Organic Chemistry, University College of Jaen, University of Granada

• MELGAREJO MIGUEL

  Department of Organic Chemistry, University of Granada

• Nogueras Manuel

  Department Of Organic Chemistry University College Of Jaen University Of Granada

• Melgarejo Miguel

  Department Of Organic Chemistry University Of Granada

• Negrillo Jacinto

  Department Of Organic Chemistry University College Of Jaen University Of Granada

関連論文

• Aminopyrimidines and Derivatives. XXI. : Synthesis of 5-Acyl-(4-β-D-glycopyranosylamino)pyrimidine Derivatives as Potential Anticancer Agents

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