Change in Digitonin-Stimulated Superoxide Anion Production by Guinea Pig Polymorphonuclear Leukocytes in Response to the Presence of Calcium Ion
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概要
- 論文の詳細を見る
Treatment of guinea pig polymorphonuclear leukocytes with digitonin in the presence of Ca^<2+> induced marked stimulation of superoxide anion production. Removal of Ca^<2+> from the incubation medium by addition of ethyleneglycolbis (β-aminoethyl ether) N, N, N', N'-tetraacetate (EGTA) either before or after the digitonin addition suppressed the stimulation of the superoxide anion production. Furthermore, readdition of Ca^<2+> in excess of the added EGTA restored the stimulatory effect of digitonin on the superoxide anion production in the leukocytes. These findings suggest the existence of reversible regulation of the digitonin-stimulated superoxide anion production by Ca^<2+>.
- 社団法人日本薬学会の論文
- 1985-06-25
著者
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岡村 直樹
広島大・医・薬
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石橋 貞彦
Department of Physiological Chemistry, Hiroshima University School of Medicine
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岡村 直樹
Department of Physiological Chemistry, Hiroshima University School of Medicine
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岡元 忠雄
Department of Physiological Chemistry, Hiroshima University School of Medicine
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岡元 忠雄
Department Of Physiological Chemistry Hiroshima University School Of Medicine
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