Potentiating Effect of Lysophosphatidylcholine on Antibacterial Activity of Polymyxin Antibiotics

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概要

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• Asolectin, a commercial crude phosphatidylcholine, which is known to inhibit the antibacterial activity of polymyxins, was studied to identify the main inhibiting substance. It was separated into several fractions by using high performance liquid chromatography (HPLC) on LiChrosorb SI 60,and each fraction was tested for effect on the antibacterial activity of colistin sulfate, one of the polymyxin group antibiotics. Most of these fractions showed various degrees of inhibiting effect but, conversely, one fraction (corresponding to lysophosphatidylcholine) potentiated the antibacterial activity of colistin. With authentic samples we confirmed that lysophosphatidylcholine showed a potentiating effect on the antibacterial activity of colistin, polymyxin B and polymyxin M. These results suggest that some detergents may be useful as potentiators of the antibacterial activity of polymyxins.

• 公益社団法人日本薬学会の論文
• 1985-04-25

著者

• 松永 久美

  武庫川女子大学 薬学部

• Matsunaga H

  Faculty Of Pharmaceutical Sciences Mukogawa Women's University

関連論文

• In Vitro Antitumor Activity of Polymyxin Acylase from Pseudomonas sp. M-6-3
• Polymxin P, Antibiotaics from Bacillus polymyxa T-39 : Fermentation, Isolation, Structure Elucidation and Antibacterial Activity
• Potentiating Effect of Lysophosphatidylcholine on Antibacterial Activity of Polymyxin Antibiotics
• オボグリコプロテインを固定化した充填剤による光学分割 : 糖鎖の光学認識に及ぼす影響
• オボグリコプロテインを固定化した充填剤による光学分割 : シアル酸の光学分割への影響

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