Synthesis of Substance P Analogs with Arginine in Position Eleven

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概要

• 論文の詳細を見る

• Substance P analogs, [Arg^<11>]-SP and SP (1-10)-Arg-OH, were synthesized by the liquid phase method. These peptides were purified by ion-exchange chromatography and partition chromatography. The biological activity of the peptides was evaluated in vitro on guinea-pig ileum. Replacement of Met^<11> in SP with Arg diminished the potency of SP activity. The analogs were found to be inactive as antagonists.

• 公益社団法人日本薬学会の論文
• 1984-10-25

著者

• 村松 一郎

  Department of Chemistry, College of Science, Rikkyo University

• 早福 昭介

  Department Of Chemistry College Of Science Rikkyo University

• 村松 一郎

  Department Of Chemistry College Of Science Rikkyo University

• 鳥越 圭介

  Department of Chemistry, College of Science, Rikkyo University

• 鳥越 圭介

  Department Of Chemistry College Of Science Rikkyo University

関連論文

• Structure-Activity Relationship of Tuftsin, a Phagocytosis-Stimulating Peptide, and Its Analogs
• Synthesis of Substance P Analogs with Arginine in Position Eleven

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