Methylation of Catechol Estrogen with Diazomethane

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概要

• 論文の詳細を見る

• Dynamic aspects of methylation of catechol estrogen with diazomethane were investigated by means of thin-layer chromatography. The methylation rate of the hydroxyl group at the C-3 position was almost the same as that of the C-2 hydroxyl group in the reaction of 2-hydroxyestrogen, and 2-3 times that of the C-4 hydroxyl group in the reaction of 4-hydroxyestrogen. In these experiments, the maximum yields of 2-methoxyestrone, 2-hydroxyestrone 3-methyl ether, 4-methoxyestrone and 4-hydroxyestrone 3-methyl ether were 32,39,13 and 70%, respectively. In addition, demethylation of catechol estrogen dimethyl ethers with boron tribromide and synthesis of 4-hydroxyestrone monomethyl ethers are described.

• 公益社団法人日本薬学会の論文
• 1983-09-25

著者

• 山崎 満

  School of Pharmacy, Hokuriku University

• 宮保 進

  School of Medicine, kanazawa University

関連論文

• Radioimmunoassay for the Determination of 2-Methoxyestriol Concentration in Plasma of Pregnent Women
• Development and Application of a Radioimmunoassay for 2-Hydroxyestriol
• Synthesis of New haptens for Radioimmunoassay of 2- and 4-Hydroxyestradiol
• Methylation of Catechol Estrogen with Diazomethane

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