Stabilization of Ampicillin Analogs in Aqueous Solution. V. Kinetic Study of the Effects of Aldehydes on the Degradation of Cephalexin in Aqueous Solution
スポンサーリンク
概要
- 論文の詳細を見る
The degradation of cephalexin (CEX) was inhibited by the addition of furfural or benzaldehyde at pH 6.00-8.50. This was due to the formation of adducts of CEX and the aldehydes at this pH region. In the acidic region (pH < 5.00) no such effects of the additives were observed because the adducts were not formed. At the pH region where the inhibitory effects are observed, CEX exhibits rate enhancement of the β-lactam cleavage due to intramolecular catalysis by the side-chain α-amino group. Since the formation constant of the adducts increased with increase of pH, the α-amino group seemed to be involved in the formation of the adducts, and this is presumably no longer available for intramolecular catalysis. The degradation rates of the adducts were smaller (about 1/10-1/1000) than those of CEX. The adducts were considered to be Schiff bases from the infrared (IR) spectra and the kinetic properties of products prepared by freeze-drying of alkaline solutions containing CEX and an aldehyde (furfural or benealdehyde).
- 社団法人日本薬学会の論文
- 1983-04-25
著者
-
藤原 洋
School Of Pharmacy Hokuriku University
-
河島 進
School of Pharmacy, Hokuriku University
-
大橋 昌子
School of Pharmacy, Hokuriku University
-
大橋 昌子
School Of Pharmacy Hokuriku University
関連論文
- Rheology of the Pharmaceutical Suspension. IV. Adsorption of Sodium Carboxymethylcellulose on Barium Sulfate Particles in Aqueous Suspension.
- Rheology of the Pharmaceutical Suspension. III. Effects of Some Additives on Viscous Behavior of Barium Sulfate-Water System.
- Studies on Sustained-Release Suppositories. III. : Rectal Absorption of Morphine in Rabbits and Prolongation of Its Absorption by Alginic Acid Addition
- Kinetic Behavior and Interaction of Bacampicillin in Alginic Acid Solution at Neural pH Region
- Studies on Sustained-Release Suppositories. II. Evaluation of Polymer Electrolyte Containing Acidic Groups for Prolonged Rectal Absorption of Bacampicillin in Rabbits
- Studies on Sustained-Release Suppositories. I. : Effect of Alginic Acid Addition on Rectal Absorption of Bacampicillin in Rabbits
- Influence of Macrogol Bases on the Bioavailability of Bacampicillin after Rectal Administration in Rabbits
- Rectal Absorption of Bacampicillin in Rabbits
- Stability of Aqueous Bacampicillin Suspension
- Kinetic Analysis of the Effect of Polyhydric Alcohols on Ampicillin Degradation in the Presence and Absence of Aldehydes in Aqueous Solution
- Stabilization of Ampicillin Analogs in Aqueous Solution. VI. Kinetic Analysis of the Stabilization Mechanism of Bacampicillin with Benzaldehyde in Aqueous Solution
- Stabilization of Ampicillin Analogs in Aqueous Solution. V. Kinetic Study of the Effects of Aldehydes on the Degradation of Cephalexin in Aqueous Solution
- Stabilization of Ampicillin Analogs in Aqueous Solution. IV. Effect of Addition of Furfural on the Degradation of Ampicillin in the Presence of Various Carbohydrates in Aqueous Solution
- Stabilization of Ampicillin Analogs in Aqueous Solution. III. Kinetics of Degradation of Ampicillin with Furfural in Aqueous Solution and Physical Properties of Ampicillin-aldehyde Adducts
- Stabilization of Ampicillin Analogs in Aqueous Solution, II. Kinetic Analysis of the Mechanism of Degradation of Ampicillin with Benzaldehyde in Aqueous Solution
- Stabilization of Ampicillin Analogs in Aqueous Solution. I. Assay of Ampicillin in Solutions containing Benzaldehyde by Iodine Colorimetry and the Effect of Benzaldehyde on the Stability of Ampicillin
- Mixing of Pharmaceutical Powders and Granules. II. Mixing Degree of Granules and Various Kinds of Powders
- Mixing of Pharmaceutical Powders and Granules. I. Effect of Grain Size on the Manufacturing Process