Studies on the Phosphorimetric Determination of Amines with Halonitro Compounds. III. Phosphorimetric Determination of 4-Homosulfanilamide with 2-Chloro-5-nitropyridine

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4-Homosulfanilamide was found to react with 2-chloro-5-nitropyridine to form 5-nitro-2-(p-sulfamoylbenzylamino)pyridine, which was strongly phosphorescent in ethanol containing 0.1% (v/v) dimethyl sulfoxide. This observation was used as the basis for a procedure to determine micro amounts of 4-homosulfanilamide, and the method was also applied to the determination of 4-homosulfanilamide added to the rat plasma. A linear relationship between the phosphorescence intensity and the amine concentration was observed in the range of 4×10^<-7>-2×10^<-5>M.
公益社団法人日本薬学会の論文
1980-03-25