Adsorption of Secretin on Glass Surfaces

概要

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Adsorption of secretin on a silicone-coated glass surface was compared with that onto a non-coated surface using controlled pore glass beads. The silicone-coated glass beads adsorbed 20 times more secretin than the non-coated beads. The adsorption was slightly affected by pH and amino acids, but was reduced to an insignificant amount in the presence of bovine serum albumin. It is suggested that the preferential adsorption of this peptide hormone onto a silicone-coated glass surface is probably the result of hydrophobic attraction between non-polar moieties of the secretin molecule and non-polar portions of the silicone membrane.
公益社団法人日本薬学会の論文
1979-12-25