Studies on the Pharmaceutical Quality Evaluation of Crude Drug Preparations used in Orient Medicine"Kampoo". II. Precipitation Reaction of Berberine and Glycyrrhizin in Aqueous Solution

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概要

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• Precipitation reaction was found to occur when each 5×10^<-4> M aqueous solution of berberine (I) and glycyrrhizin (II) were blended. The molar ratio of I and II in the precipitate (III) was revealed to be 2 : 1 by observation of UV absorption at 251 and 350 nm. By comparison of the IR absorption near at 1715 and 1620 cm^<-1> of II, III, soyasaponin III and glycyrrhetinic acid after treated at various pH, it was revealed that the quartery base moiety of I bound on the glucouronic acid moieties of II ionically in compound III. The solubility of III in aqueous solution was 0.09% at pH 3.5,while it increased up to 1.9% at pH 6.8. The solubility of III was slightly decreased by addition of II in aqueous solution.

• 公益社団法人日本薬学会の論文
• 1978-09-25

著者

• 野口 衛

  National Institute Of Hygienic Sciences Osaka Branch

関連論文

• Studies on the Pharmaceutical Quality Evaluation of Crude Drug Preparations used in Orient Medicine "Kampoo". III. Precipitation Reaction of Glycyrrhizin with Alkaloids or Alkaloidal Crude Drugs in Aqueous Solution
• Studies on the Pharmaceutical Quality Evaluation of Crude Drug Preparations used in Orient Medicine"Kampoo". II. Precipitation Reaction of Berberine and Glycyrrhizin in Aqueous Solution

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