Crystal Forms and Optical Resolution by Preferential Crystallization of Calcium DL-Pantothenate

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概要

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• Five polymorphs (A-, B-, C-, D- and E-form), four solvates (monohydrate, a hydrate contained 3/4 molecule of water, methanol monosolvate and a solvate contained 4 molecules of methanol and 1 molecule of water) and an amorphous form of calcium DL-pantothenate were isolated. These crystal forms were characterized using thermal analysis, X-ray powder diffraction and infrared spectroscopy. In order to examine the resolution of calcium DL-pantothenate by preferential crystallization, the racemic structures of these crystal forms were investigated by comparing these physical properties with those of crystal forms of calcium D (+)-pantothenate. As the results, C-form and the solvate contained 4 molecules of methanol and 1 molecule of water were found to be the racemic mixtures and then the optical resolutions of the two kinds of crystals were carried out.

• 公益社団法人日本薬学会の論文
• 1977-05-25

著者

• 稲垣 正博

  Research Institute Daiichi Seiyaku Co. Ltd.

関連論文

• Crystal Forms of Calcium D (+)-Pantothenate
• Some Aspects on the Optical Resolution by Preferential Crystallization based on Phase Equilibrium
• Crystal Forms and Optical Resolution by Preferential Crystallization of Calcium DL-Pantothenate

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