Changes of Some Properties of Blood of Rats administered with Methylmercuric Chloride

概要

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Methylmercuric chloride (MMC, CH_3HgCl) was adminsitered to male Wistar rats weighing 150-160 g by subcutaneous injection in a daily dose of 1 mg or 0.4 mg per 100 g body weight to produce an acute (for 12 days, 20 rats) or a subacute intoxication (for 28 days, 20 rats). Hematocrit value decreased from 37% (control group) to 27% (MMC administered groups) with decreasing body weight. About 90% of total mercury in the blood (ca. 95μg Hg/ml) of rats of the two MMC-treated groups was distributed in the erythrocytes. The shapes of erythrocytes (acute and subacute intoxications) became the spicule cells like acanthocyte. The osmotic fragility of erythrocytes of rats with acute intoxication clearly decreased, but oxygen capacity per ml of the erythrocytes did not change. Then, the properties of the erythrocytes incubated with various concentrations (44,72,170 μg Hg/ml) of MMC for 60 min at 37°were studied. Spicule cells like echinocyte II increased with increasing mercury amount into erythrocytes. However, the osmotic fragility and oxygen capacity per ml of the erythrocytes were unchanged.
公益社団法人日本薬学会の論文
1977-02-25