Cobalt Chelate of Bleomycin. II. Binding to Deoxyribonucleic Acid of Ehrlich Solid Tumor in Mice

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概要

• 論文の詳細を見る

• Cobalt chelate of bleomycin (Co-BLM) bound deoxyribonucleic acid (DNA) was purified from Ehrlich solid tumor of mice administered with Co-BLM by the extraction from the purified nuclei. In both ^<57>Co-BLM and Co-BLM (^<14>C), the DNA was taken in 99% purity, and the decrease in the specific radioactivity of the Co-BLM=DNA complex was minimized in the course of the purification procedure. The complex was stable in the Sephadex G-100,hydroxyapatite columns and neutral sucrose gradient solution. Moreover, this was stable in the electrophoretic conditions. However, Co-BLM dissociated from DNA by acid, alkaline or heat treatment.

• 公益社団法人日本薬学会の論文
• 1977-11-25

著者

• 河野 彬

  Faculty Of Pharmaceutical Sciences Kyushu University

関連論文

• Radiation-Inactivation of Aspartate Aminotransferase and Its Protection by 2-Mercaptoethylamine and 2-Aminoethylisothiuronium Bromide
• Cobalt Chelate of Bleomycin. II. Binding to Deoxyribonucleic Acid of Ehrlich Solid Tumor in Mice

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