Mode of Action of Menaquinone-4 on Blood Coagulation
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概要
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The prothrombin activity in plasma was highly correlated with that in liver in normal rats, bishydroxycoumarin (dicumarol)-treated rats and CCl_4-treated rats. Menaquinone-4(K_<2(20)>) significantly increased the prothrombin activities in plasma and in liver of rats which had hypoprothrombinemia induced by administration of dicumarol or CCl_4. K_<2(20)> significantly promoted the prothrombin synthesis in liver homogenate in the rats treated with dicumarol or CCl_4. Furthermore, it was observed that K_<2(20)> exerted a promoting effect on prothrombin synthesis in the microsomal fraction of liver. However, when plasma was incubated with K_<2(20)>, the prothrombin time of the plasma was not shortened. The effects of K_<2(20)> on the prothrombin activity and on the prothrombin synthesis of liver were more rapid and stronger than those of vitamin K_1. It is concluded that K_<2(20)> promotes prothrombin synthesis in liver parenchymal cells and improves hypoprothrombinemia caused by dicumarol or CCl_4 in rats.
- 公益社団法人日本薬学会の論文
- 1975-09-25