Studies of Peptide Antibiotics. XXVI. Syntheses of Cyclodipeptides containing N^δ-p-Aminobenzenesulfonyl Ornithine Residue

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概要

• 論文の詳細を見る

• A cyclo-N^δ-p-aminobenzenesulfonyl-L-ornithyl-L-leucyl (LL-X) was prepared through the cyclization reaction of N^δ-p-aminobenzenesulfonyl-L-ornithyl-L-leucine ethyl ester with methanolic ammonia. Other three diastereomeric cyclodipeptides (DD-X, LD-X, and DL-X) and cyclo-N^δ-p-aminobenzenesulfonyl-ornithyl-glycyls (L and D form) were synthesized in the same manner. All p-aminobenzenesulfonyl cyclodipeptides showed no antibacterial activity against Escherichia coli and Bacillus subtilis even at the concentration of 1000 μg/ml.

• 公益社団法人日本薬学会の論文
• 1972-09-25

著者

• 池田 国樹

  Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd.,

• 泉屋 信夫

  Faculty of Engineering, Kyushu Sangyo University

• 池田 国樹

  Faculty of Science, Kyushu University

• 黒水 健治

  Faculty of Science, Kyushu University

• 岡元 孝二

  Faculty of Science, Kyushu University

• 岡元 孝二

  Faculty Of Science Kyushu University

• 池田 国樹

  Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.

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• Synthesis and Biological Activities of Optical Isomers of 2-(4-Chlorophenyl)-5,6-dihydro-(1)benzothiepino[5,4-c]pyridazin-3(2H)-one 7-Oxide
• Molecular Rotations of N^α-Acyl-L-lysines at Various pH Values
• Studies of Peptide Antibiotics. XXVI. Syntheses of Cyclodipeptides containing N^δ-p-Aminobenzenesulfonyl Ornithine Residue

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