A Novel Preparation and Reaction of 2,1-Benzisothiazole Derivatives

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概要

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• 2,1-Benzisoxazole derivatives were converted into 2,1-benzisothiazoles simply by fusing with phosphorus pentasulfide in imidazole. 1-Alkyl-2,1-benzisothiazolium salts, prepared by alkylation of 2,1-benzisothiazoles with trialkyl orthoformates in the presence of Lewis acids, were shown to react with amines to afford 2,1-benzisothiazoline derivatives and with glycine ethyl ester to form a 1,4-benzodiazepin-2-one derivative by the extrusion of the sulfur atom.

• 公益社団法人日本薬学会の論文
• 1972-11-25

著者

• 安芸 修躬

  Central Research Divistion, Takeda Chemical Industries, Ltd.

• 安芸 修躬

  Central Research Divistion Takeda Chemical Industries Ltd.

• 白川 研蔵

  Central Research Division Takeda Chemical Industries Ltd.

• 中川 康

  Central Research Division, Takeda Chemical Industries, Ltd.

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• S-Alkylthioisothioureas. I
• A Novel Preparation and Reaction of 2,1-Benzisothiazole Derivatives
• Synthesis and Reactions of 1-Alkyl-2,1-benzisoxazolium Salts
• S-Alkylthioisothioureas. II. Reactions of S-Alkylthioisothioureas with Some Active Methylene Compounds and Secondary Amines
• The Vilsmeier-Haack Reaction of Lactams : Chloroformylation of 1,3,4,5-Tetrahydro-2H-1-benzazepin-2-one and 2H-1,4-Thiazin-3-ones

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