Studies on Hard Gelatin Capsules. II. The Capsule Filling on Powders and Effects of Glidant by Ring Filling Method-Machine

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The filling characteristics of capsules were studied on cornstarch and lactose with and without Aerosil as glidant, using industrially semiautomatic-ring filling method-machine with the flat and the screw auger. On powders without Aerosil, the coefficient of variation of the dose showed that the filling by the screw auger was more accurate than that by the flat one. Deviations of the dose containing Aerosil became smaller and showed maximum effect between 0.1-2% Aerosil contents. The maximum filled weights were observed at 0.1-0.5% Aerosil contents but on lactose filling by the screw auger the filled weight decreased with Aerosil contents. The filled weight variation was compared with U. S. P. requirements. As the approach to reviewing the filling properties, two usual packing equations were applied for the relation between the filled weight and velocity of the ring.
社団法人日本薬学会の論文
1969-06-25