2-Amino-4-hydroxy-1,4,5,6-tetrahydropyrimidine, Its Preparation and Reaction

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概要

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• 2-Amino-4-hydroxy-1,4,5,6-tetrahydropyrimidine (I), the cyclic guanidine moiety of tetrodotoxin, and its derivatives were prepared to examine their chemical and physical properties in comparison with the toxin and its derivatives. 1. Oxidation of I with chromium trioxide-pyridine gave β-alacreatinine (III). 2. Etherification of I with alcohols in the presence of acid catalyst afforded the corresponding 4-alkoxy derivatives (IV and V). 3. Acetylation of I under various conditions gave N-acetyl derivative (VI), O-acetyl derivative (VII), and N-acetyl-1,6-dihydro derivative (VIII) respectively. 4. Interconversion of the acetyl derivatives is also described.

• 公益社団法人日本薬学会の論文
• 1968-05-25

著者

• 鈴木 英次

  Faculty Of Pharmacy Meijo University

• 後藤 俊夫

  Department of Agricultural Chemistry, Nagoya University

• 後藤 俊夫

  Department Of Agricultural Chemistry Nagoya University

関連論文

• 2-Amino-4-hydroxy-1,4,5,6-tetrahydropyrimidine, Its Preparation and Reaction
• Studies on Pyrimidine Derivatives. X
• Studies on Pyrimidine Derivatives. IX. Synthesis of Some Alkylamino- and Alkylthio-, Thiazolo (5,4-d) pyrimidines. (2)
• Studies on Pyrimidine Derivatives. VIII. Synthesis of Some Alkylamino- and Alkylthio-, Thiazolo (5,4-d) pyrimidines. (1)
• Laser-Induced-Fluorescence Study of SiH2 in a RF SiH4/SiH2Cl2 Plasma (レ-ザ-および放射光の半導体プロセス分野への応用特集号)

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