Experimental Anticancer Studies. XXXVI. The Effect of 2-(2-Hydroxyphenyliminomethyl)-4-n-hexylphenol on Ribonucleic Acid Synthesis and Energy Metabolism in Bacillus subtilis

スポンサーリンク

概要

• 論文の詳細を見る

• In order to obtain some information on the action mechanism of 2-(2-hydroxyphenyliminomethyl)-4-n-hexylphenol (II) as a possible anticancer agent a series of experiments were performed, in which the influence of II on macromolecular synthesis and energy metabolism was examined employing B. subtilis in vitro. As the results, net synthesis of RNA was fairly inhibited by II at the level of 10μM, though DNA and protein syntheses were less affected under the same conditions. Both respiration and anaerobic glycolysis of the bacterial cell were suppressed at the concentration of 33.3μM or more of II. Then, it might be postulated that depression of RNA synthesis in one hand and suppression of respiration and anaerobic glycolysis in the other are responsible for the inhibition of the bacterial growth. Additionally, experimental data suggest that metal chelating ability of II might be contributing to the antibacterial action, because the inhibition of bacterial growth by II could be almost completely reversed by either Fe^<2+>, or Fe^<3+>, or Mn^<2+>.

• 公益社団法人日本薬学会の論文
• 1968-12-25

著者

• 氏家 俊光

  Department of Chemistry, Research Institute of Tuberculosis, Kanazawa University

• 氏家 俊光

  Department Of Experimental Therapeuticus Cancer Research Institute Kanuzawa University

関連論文

• Experimental Anticancer Studies. XVI. Preparation and Anticancer Activity of 4-Amino-6-hexylresorcinol on Ehrlich Carcinoma in Mice.
• Action Mechanism of 2-(2-Hydroxy-5-n-hexylphenyl)-8-quinolinol-4-carboxylic Acid-with Special Reference to Selective Inhibition of DNA Synthesis in Ascites Hepatoma AH 13 Cells in Culture
• 2-(2-Hydroxy-5-n-hexylphenyl)-8-quinolinol-4-carboxylic Acid and Its Related Compounds-Anticancer and Other Biological Activities
• Anticancer Activity of 2-(2-(5-Nitro-2-furyl) vinyl)-8-(β-(N, N-Diethylamino) ethoxy) quinoline
• Experimental Anticancer Studies. XXXVI. The Effect of 2-(2-Hydroxyphenyliminomethyl)-4-n-hexylphenol on Ribonucleic Acid Synthesis and Energy Metabolism in Bacillus subtilis
• Experimental Anticancer Studies. XXXIV. Some Compounds relating to 4-n-Hexyl-6-(2-Hydroxyphenyliminomethyl) resorcinol and Their Anticancer Activity
• Experimental Anticancer Studies. XXVIII. Anticancer Activity of Some Nitrofuran Derivatives.

スポンサーリンク