Structure-Activity Relationship of Colistins.

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概要

• 論文の詳細を見る

• 1) Purified samples of polymyxin group antibiotics were shown to be remarkable antimicrobial agents as colistin against E. coli. 2) Removal of the C_9-fatty acid from the colistin molecule resulted in the decrease of the activity. 3) The side chain moiety itself showed no antimicrobial activity. 4) The cyclic peptide moiety showed an antimicrobial activity although it was less active than the parent antibiotic. These results indicate that the "active"structure responsible for the antimicrobial activity is the"cyclic peptide moiety"in colistin molecule.

• 公益社団法人日本薬学会の論文
• 1967-08-25

著者

• 中島 久二瑛

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University

• 中島 久二瑛

  Department Of Experimental Chemotherapy Research Institute For Microbial Diseases Osaka University

関連論文

• Studies on the Anticancer Activity of Phenazine Derivatives
• Structure-Activity Relationship of Colistins.

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