The Mechanism of Solubilization of Water Insoluble Substances with Sodium Benzoate Derivatives. III. Decrease of Activity Coefficient of Water Insoluble Substances by Addition of Sodium Benzoate Derivatives in Aqueous Systems
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In the previous reports, it was suggested that as the mechanism of the solubilization by sodium benzoate derivatives, another factor than complex formation. between solubilizing and solubilized molecules had to be considered. In this paper, it was proved that the activity coefficients of water insoluble substances in aqueous solutions decreased by addition of sodium benzoate derivatives. It was concluded that the mechanism of the solubilization by sodium benzoate derivatives composed of the two main factors, one of which was complex formation between solubilizied and solubilizing molecules and the other of which was the salting in effect of sodium benzoate derivatives.
- 公益社団法人日本薬学会の論文
- 1966-01-25
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