Chemical and Chemotherapeutical Studies on the Furan Derivatives. XXXVII. Studies on the Phage Inducing Activity on Escherichia coli K12(λ) of Nitrofuranquinoline Compounds

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概要

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• Sixteen nitrofurylvinylquinoline compounds were examined for their phage inducing activity on E. coli K 12 (λ), a lysogenic strain. Excepting compounds having -COOH, -CONH_2,-NO_2,or -Br on the quinoline nucleus, they had phage inducing ability. The compound, 4,6-Diamino-2Q-ran HCl was the strongest among them and its activity was twice as strong as that of Mitomycin C, a drug for cancer. It is a notable fact that the tested nitrofurylvinylquinoline compounds which have an inducing activity in lysogenic bacteria exhibit, with one exception, an antitumor effect on bearing Ehrlich ascites carcinoma.

• 公益社団法人日本薬学会の論文
• 1965-05-25

著者

• 三浦 孝次

  Faculty Of Pharmacy Kanazawa University

• 岡田 いく子

  Faculty Of Pharmacy Kanazawa University

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