Studies on Pyridazine Derivatives. V. Syntheses of 5-Substituted Derivatives of 3-Amino-6-alkoxypyridazine 2-Oxide.

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概要

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• In order to find antimicrobial agents, the substitution of 3-acetamido-6-alkoxypyridazine 2-oxide was investigated. As the results obtained, it was made clear that a number of 3-acetamido-6-alkoxypyridazine, 3-amino-6-alkoxypyridazine and their 2-oxides having such a substituent group as nitro, amino, hydroxyamino, azo, hydrazo, chloro, methoxy, methylthio, hydroxy, and mercapto at 5-position of the pyridazine rings, were synthesized. This finding is of use to develope the chemistry of pyridazine. Among these new compounds, 3-acetamido-and 3-amino-5-nitro-6-alkoxypyridazine 2-oxides were found to exert excellent in vitro effects on pathogenic bacteria.

• 公益社団法人日本薬学会の論文
• 1963-09-25

著者

• Horie Tatsuya

  Pharmaceutical Institute Keio-gijuku University

• Horie T.

  Pharmaceutical Institute, Keio-Gijuku University

関連論文

• Studies on Pyridazine Derivatives. V. Syntheses of 5-Substituted Derivatives of 3-Amino-6-alkoxypyridazine 2-Oxide.

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