Syntheses of Ring-substituted Flavonoids and Allied Compounds. X. Synthesis of Ginkgetin.

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概要

• 論文の詳細を見る

• The condensation of 3'-iodo-5-benzoyloxy-4', 7-dimethoxyflavone and 5-benzoyloxy-8-iodo-4', 7-dibenzyloxyflavone was carried out at 225〜230°for 40 minutes, with activated copper powder. The chloroform extract of the reaction mixture was heated with 10% H_2SO_4 in AcOH at 110° for 10 minutes to hydrolyze benzoyl and benzyl groups. The hydrolysate was dissolved in a mixture of dioxane and ether, and shaken with 10% K_2CO_3 solution to obtain yellow, sandy crystalline precipitate of potassium salt of ginkgetin. This salt was purified by recrystallization from 10% K_2CO_3 solution, decomposed with dilute H_2SO_4,and the free ginkgetin obtained was recrystallized from methyl ethyl ketone to pale yellow, small plates, m.p. 336°. Its acetate formed colorless needles, m.p. 259°. Ginkgetin and its acetate synthesized above were respectively identified with the corresponding materials of natural origin.

• 公益社団法人日本薬学会の論文
• 1963-03-25

著者

• 中沢 浩一

  Sanwa Kagaku Kenkyusho Co. Ltd.

• 伊藤 万蔵

  Gifu College Of Pharmacy

• 中沢 浩一

  Gifu College of Pharmacy

関連論文

• Syntheses of Ring-substituted Flavonoids and Allied Compounds. XII. Synthesis of (±)-Fukugetin Heptamethyl Ether
• Synthesis of (±)-Fukugetin Heptamethyl Ether
• Syntheses of Ring-substituted Flavonoids and Allied Compounds. X. Synthesis of Ginkgetin.
• Syntheses of Ring-substituted Flavonoids and Allied Compounds. XI. Synthesis of Hinokiflavone
• Syntheses of Nuclear-substituted Flavonoids and Allied Compounds. IX. Syntheses of Tetramethyl Ether and Dimethyl Ether of Ginkgetin.
• Synthesis of Ginkgetin Tetramethyl Ether

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