Application of Surface Active Agents in Pharmaceutical Preparations. XI. Inactivation of p-Hydroxybenzoic Acid Esters in the Solubilized Solution of Oily Substances.

概要

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Investigations were made on an inactivation of p-hydroxybenzoic acid ester when they were incorporated into preparations in which oily substances are solubilized. Oily substances, such as isopropyl myristate, olive oil, lauryl alcohol, xylene and dibutyl phthalate, considerably interferred with the activity of esters dependent upon the amount and the property of oily substances incorporated. Propyl p-hydroxybenzoate was found more subject to inactivation than the methyl ester whenever oily substances were employed. It was suggested that the propyl ester was highly inactivated by easy solubilization into the lipophilic part of the micelle which consisted of a surfactant and an oily substance.
社団法人日本薬学会の論文
1962-04-25