Studies on Acylase Activity and Microorganisms. XXI. Optical Resolution of Higher Amino Acids by Acylase of Soil Bacteria.

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概要

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• The acylase activity of a strain (KT 218) of soil bacteria was tested against N-benzoyl and N-dichloroacetyl derivatives of 2-aminooctanoic, 2-aminodecanoic, 2-aminolauric, 2-aminomyristic, and 2-aminopalmitic acid. It was revealed that the dichloroacetylaminoacids were more easily hydrolyzed than the corresponding benzoylamino acids and that the N-dichloroacetyl-derivatives of the homologous series of straight chain 2-aminoacid were hydrolyzed at progressively decreasing rates from N-dichloroacetyl-DL-2-aminooctanoic acid to N-dichloroacetyl-DL-2-aminopalmitic acid which was resistant to KT 218 acylase. The acetone powder of KT 218 effected asymmetric hydrolysis of N-dichloroacetyl derivatives of 2-aminooctanoic, 2-aminodecanoic, 2-aminolauric, 2-aminomyristic acids to yield respectively L-2-aminooctanoic acid (XI) and N-dichloroacetyl-D-2-aminooctanoic acid (XV), L-2-aminodecanoic acid (XII) and N-dichloroacetyl-D-2-aminodecanoic acid (XVI), L-2-aminolauric acid (XIII) and N-dichloroacetyl-D-2-aminolauric acid (XVII), and L-2-aminomyristic acid (XIV) and impure N-dichloroacetyl-D-2-aminomyristic acid. In the same way KT 218 acetone powder effected asymmetric hydrolysis of N-benzoyl derivatives of 2-aminooctanoic, 2-aminodecanoic, and 2-aminolauric acids to yield respectively L-2-aminooctanoic acid (XI) and N-benzoyl-D-2-aminooctanoic acid (XVIII), L-2-aminodecanoic acid (XII) and impure N-benzoyl-D-2-aminodecanoic acid, and L-2-aminolauric acid (XIII) and impure N-benzoyl-D-2-aminolauric acid.

• 社団法人日本薬学会の論文
• 1962-12-25

著者

• 木村 行男

  Faculty Of Pharmaceutical Sciences Mukogawa Women's University

• 木村 行男

  Laboratory of Antibiotics, Faculty of Pharmacy, Kanazawa University

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• Reversed-Phase High-Performance Liquid Chromatographic Determination of Gliclazide in Human Plasma
• Studies on Acylase Activity and Microorganisms. XXI. Optical Resolution of Higher Amino Acids by Acylase of Soil Bacteria.
• Studies on Acylase Activity and Microorganisms. XVII. Optical Resolution of Tryptophan, 2-Aminohexanedioic Acid, and 2-Aminooctanoic Acid by Metabolism of Soil Bacteria on Benzoyl Derivatives of DL-Amino Acids.
• Studies on Acylase Activity and Microorganisms. IX. Enzymatic Resolution of Tryptophan by a Strain of Soil Bacteria.
• Studies on Acylase Activity and Microorganisms. VIII. Enzymatic Hydrolysis of 6-N-Benzoyl-L-lysine.
• A Certain Strain of Soil Bacteria capable of metabolizing D-Forms but not L-Forms of threo-2-Phenylserine and Its Benzoyl Derivative

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