Analytical Studies on Antileprous Drugs. V. On the Metabolic Difference of Promin and 4,4'-Diaminodiphenyl Sulfone in the Urine and Plasma of Rabbits
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Metabolic difference between Promin and 4,4'-diaminodiphenyl sulfone was investigated using urine and plasma of rabbits. It was clarified that Promin is metabolized mainly to N-glucoside of 4,4'-diaminodiphenyl sulfone, receiving desulfonation. Further, N-conjugation was not clearly proved, being different from 4,4'-diaminodiphenyl sulfone which was metabolized to mono-N-conjugates.
- 公益社団法人日本薬学会の論文
- 1961-06-25
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関連論文
- Analytical Studies on Antileprous Drugs. V. On the Metabolic Difference of Promin and 4,4'-Diaminodiphenyl Sulfone in the Urine and Plasma of Rabbits
- Analytical Studies on Antileprous Drugs. IV. On the Metabolic Substances of Human and Rabbit Urine after Administration of 4,4'-Diaminodiphenyl Sulfone and 4,4'-Diaminodiphenyl Sulfoxide, with Special Reference to Labile N-Conjugates.