New Fat-soluble Derivatives of Pyridoxine prepared by Selective Acylation.
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概要
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Acylation of pyridoxine (I) with fatty acid chloride in pyridine and chloroform at room temperature gave pyridoxine diacylates (II), which were verified to be the 3,4-diacylates. The diacylates prepared and the triacylates obtained as a by-product are listed in Table I. The long-chain fatty acid derivatives (II) are stable to heat and soluble in fat. Pyridoxine 3,4-dipalmitate (II b) showed a complete pyridoxine activity in mice by oral or dietary administration.
- 公益社団法人日本薬学会の論文
- 1961-03-25
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