Synthesis in the Morphinan Group. III. A Synthesis of 2,3-and 3,4-Ethylenedioxy-N-methylmorphinan and their Optical Resolution
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For phamacological evaluation, 2,3-and 3,4-ethylenedioxy-N-methylmorphinans were prepared. 3,4-Ethylenedioxyphenylacetic acid was prepared through two different ways; 6-formylbenzodioxane was converted to the amide, from which two N-methylmorphinan were obtained according to the method of Schnider. The Structrues of the two isomeric N-methylmorphinans were cofirmed by infrared spectral data. 3,4-Ethylenedioxy-N-methylmorphinan was resolved into the optical antipodes, using bibenzoyl-d-tartaric acid.
- 公益社団法人日本薬学会の論文
- 1960-04-25
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