δ-Hydroxy-γ-oxo-L-norvaline, a New Antitubercular Antibiotic. (2). Synthetic Studies.
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概要
- 論文の詳細を見る
The structure of δ-hydroxy-γ-oxo-L-norvaline was proposed for the new antibiotic, HON. This compound was synthesized through two different routes. Optical resolution of the racemate was achieved by fractional crystallization of brucine salts of N-acetyl-δ-hydroxy-γ-oxo-DL-norvaline. Physicochemical and microbiological properties of the synthesized δ-hydroxy-γ-oxo-L-norvaline revealed that this compound was identical with naturally occurring L-HON.
- 公益社団法人日本薬学会の論文
- 1960-12-25
著者
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三宅 彰
Research Laboratories, Takeda Chemical Industries, Ltd.
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三宅 彰
Research Laboratories Takeda Pharmaceutical Industries Ltd.
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