Synthesis and Antibacterial Activity of Cystine Derivatives. II.

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概要

• 論文の詳細を見る

• L-Cystine dihydrazide and L-cystine bis (p-alkoxyanilide) derivatives listed in Tables I, II, and III were prepared and submitted to antibacterial tests with Mycobacterium tuberculosis. Two methods were used for the synthesis of these compounds. The one was du Vigneaud's method and the other was a new route to cysteinyl peptides. In the antibacterial test in vitro, the strongest activity among these compounds was found in L-cystine bis (isonicotinoylhydrazide) which was inhibitory in a concentration of 0.1γ/cc. L-Cystine bis (p-pentyloxyanilide) showed antibacterial action in the range of 1〜0.3γ/cc.

• 公益社団法人日本薬学会の論文
• 1959-06-10

著者

• 三好 文彦

  フナイ総合研究所

• 榊原 栄一

  フナイ総合研究所

• 佐野 安雄

  Pharmaceutical Faculty University Of Osaka

• 谷山 兵三

  Pharmaceutical Faculty University Of Osaka

• 三好 文彦

  Pharmaceutical Faculty, University of Osaka

• 久保田 聰一

  Pharmaceutical Faculty, University of Osaka

• 榊原 栄一

  Osaka University of Liberal Arts and Education

• 内田 誉

  National Sanatorium Toneyama Hospital

• 久保田 聰一

  Pharmaceutical Faculty University Of Osaka

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