Studies on Tannins. VIII. Effect of Tannins and Related Compounds on Cysteine Desulfhydrase Activity of Escherichia coli.

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概要

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• The enzymatic production of hydrogen sulfide by E. coli was inhibited by most of the tannins and related compounds tested. Inhibition by polyhydroxyl compounds lacking free carboxyl group is greater than that by polyhydroxycarboxylic acids. The inhibition is not competitive with substrate, nor is it reversed by the addition of a coenzyme. In order to attain a maximal inhibition it is necessary to incubate the cells with an inhibitor for a certain length of time prior to addition of the substrate. Cysteine is able to partially protect the enzyme from the action of inhibitors. This protecting effect is more pronounced when the substrate and inhibitor are incubated and then added to the reaction mixture. Inhibition by gallic acid is considerably enhanced by aerating the inhibitor solution. This suggests that the oxidized form of gallic acid is more inhibitory than gallic acid itself. There are many differences between the mechanisms of inhibition by gallic acid and d-catechin.

• 社団法人日本薬学会の論文
• 1959-06-10

著者

• 木村 康一

  Faculty Of Pharmacy Kyoto University

• 木村 康一

  Pharmaceutical Faculty, University of Osaka

• 山内 和子

  Pharmaceutical Faculty, University of Osaka

• 桑野 重昭

  Pharmaceutical Faculty, University of Osaka

関連論文

• Structure of Dendropanoxide, a new Triterpenoid from the Leaves of Dendropanax trifidus MAKINO
• Anodic Synthesis of Fatty Acids. VI. The Syntheses of ω-Hydroxylated Fatty Acids and ω, ω'-Diols.
• Studies on Tannins. IX. Effect of Tannins and Related Compounds on Tryptophanase Activity of Escherichia coli.
• Studies on Tannins. VIII. Effect of Tannins and Related Compounds on Cysteine Desulfhydrase Activity of Escherichia coli.
• Anodic Synthesis of Fatty Acids. II. : The Syntheses of 3,3-Dimethylated Branched Acids.
• Studies on the Constituents of Ephedra. I. Determination of Alkaloids in Ephedra.

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