Studies on the Metabolism of Naturally Occurring Coumarins. V. Urinary Metabolites of Coumarin and Dihydrocoumarin.
スポンサーリンク
概要
- 論文の詳細を見る
Studies on the metabolic fate of coumarin and dihydrocoumarin have been elucidated. Coumarin was mainly hydroxylated to 3-hydroxycoumarin, umbelliferone, and a trace of 8-hydroxycoumarin. o-Coumaric acid was subjected to opening of the lactone ring and glycine conjugates of o-coumaric acid and melilotic acid were detected in the metabolite. Hydroxylated compounds were conjugated with glucuronic and sulfuric acids. Various metabolites derived from dihydrocoumarin were also detected by paper chromatography. A scheme of metabolic process of coumarin and dihydrocoumarin was also proposed and discussed.
- 公益社団法人日本薬学会の論文
- 1958-12-15
著者
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古谷 力
College of Pharmaceutical Sciences, Kitasato University
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古谷 力
College Of Pharmaceutical Sciences Kitasato University
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古谷 力
Faculty of Pharmaceutical Sciences, University of Tokyo
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