Reduction of Substituted Resorcinols. IV. Synthesis of 2-Carbamoyl-4-dimethylaminocyclohexane-1,3-dione and Related Compounds.

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概要

• 論文の詳細を見る

• Under the assumption that the characteristic A-ring in the tetracyclines was responsible for the remarkable antibacterial activity of these antibiotics, syntheses of the A-ring and related compounds were undertaken to examine relationship between chemical structure and antibacterial activity. Following the syntheses of 4-benzamido-, 4-dimethylamino-, and 2-carbamoyl-cyclohexane-1,3-dione and their derivatives, the A-ring itself of the tetracyclines, 2-carbamoyl-4-dimethylaminocyclohexane-1,3-dione, and its derivatives were prepared.

• 公益社団法人日本薬学会の論文
• 1958-12-15

著者

• 冨野 耕一

  Osaka Research Laboratory Tanabe Seiyaku Co. Ltd.

関連論文

• Reduction of Substituted Resorcinols. IV. Synthesis of 2-Carbamoyl-4-dimethylaminocyclohexane-1,3-dione and Related Compounds.

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