Steroid Studies. VII. Syntheses of Sargasterol, Fucosterol, and C_<20>-Isocholesterol.

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概要

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• Synthesis of sargasterol (isolated from Sargassum ringgoldianum HARV.) was carried out from 3β-acetoxy-20-iso-⊿^5-bisnorcholenic acid as a starting material. Fucosterol (isolated from several brown algae) was also prepared from 3β-acetoxy-⊿^5-bisnorcholenic acid by the same procedure. These synthesized sargasterol and fucosterol were respectively identical with natural sargasterol and fucosterol. Wolff-Kishner reduction of 22-oxo-20-isocholesterol, prepared from 22-oxocholesterol by isomerization, afforded 20-isocholesterol. 22-Hydroxycholesterol was prepared from 22-oxocholesterol by reduction with sodium borohydride and this sterol was identical with a sample isolated from a lily sterol.

• 公益社団法人日本薬学会の論文
• 1957-10-20

著者

• 早津 了一

  Takamine Research Laboratory, Sankyo Co., Ltd.

• 早津 了一

  Takamine Research Laboratory Sankyo Co. Ltd.

関連論文

• On the Constitution of Tetrodotoxin
• Steroid Studies. VII. Syntheses of Sargasterol, Fucosterol, and C_-Isocholesterol.
• Studies on Cholestapolyenes. I. : Syntheses of Bicholestatriene A and 7-Dehydrocholesterol.
• Untersuchungen uber Steroide. IX. Die Sterine aus Meeres-algen.
• Uber die Konfiguration am Kohlenstoffatom-22 des naturlichen 22-Hydroxycholesterins
• Sargasterol from Sargassum Ringgoldianum HARVEY
• Transition of N-Cholestenylpyridinium Salts. II. : Partial Synthesis of 3 (β)-Carboxycholestene-5.

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