Adrenochrome誘導体の研究(第5報)Adrenochrome Monosemicarbazone及び類縁化合物の可溶化その1 4β-Hydroxyethylsemicarbazone類の合成

概要

論文の詳細を見る
Adrenochrome monosemicarbazone is sparingly soluble in water (0.3 mg./cc. at 0°), that there is some difficulty in preparing highly concentrated solutions. Urea is generally used as the solubilization agent but this substance was found to be ineffective in this case. β-Hydroxyethylurea, introduced with the soluble hydroxyethyl group, was also ineffective. However, adrenochrome 4-β-hydroxyethylsemicarbazone was found to be 3.5 times more soluble than the ordinary monosemicarbazone. 4-β-Hydroxyethylsemicarbazones were prepared of three compounds of 5,6-dioxo-2,3,5,6-tetrahydroindole type^<5α)> and two compounds of 6,7-dioxo-1,2,3,4,6,7-hexahydroquinoline type^<1)> and they were all found to be far more easily soluble than the monosemicarbazones. 4-β-Hydroxyethylsemicarbazide was prepared by heating acetone semicarbazone and monoethanolamine at 180° to form acetone 4-β-hydroxyethylsemicarbazone and its hydrolysis with mineral acid.
公益社団法人日本薬学会の論文
1956-08-25