核酸の生合成に関する研究(第1報)ボリヌクレオタイドプリン体の先駆物質としての4-アミノイミダゾールカルボキサミドの役割について

概要

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By employing 4-aminoimidazole[4-^<14>C]-5-carboxamide, formate-^<14>C, and ^<32>P, the role of the carboxamide as a precursor of polynucleotide purines was examined. The in vitro incorporation of the labeled carboxamide into polynucleotide adenine and guanine was found by rat liver slices and by cell-free system. The specific activity was about 2〜5 times higher in adenine than in guanine. In the case of regenerating liver, generally higher specific activity was observed than in the case of normal liver. The stimulatory effect of the non-labeled carboxamide in the course of the incorporation of formate-^<14>C and ^<32>P into polynucleotides was demonstrated.
公益社団法人日本薬学会の論文
1956-04-20